Klotzer’s career in journalism began in 1948 as assistant editor of at the Troy (Ill.) Tribune working for 19 year-old future Illinois senator Paul Simon, then the editor and publisher. He was founder of the Greater St. Louis Jewish Star and later, editor of the St. Louis Jewish Light. Klotzer and his wife Rose launched FOCUS/Midwest, a monthly dealing with the social, political and racial issues of the 1960s. In 1970, they founded, with the help of area journalists, academicians and social activists the St. Louis Journalism Review. In 1983, the two publications merged, becoming the only local media review in the country. Through most of its existence, the St. Louis Journalism Review was financed completely by the Klotzers.